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Global Response to B6 Toxicity

Vitamin B6 Upper Limit Guidelines by International Regulatory Agencies

AgencyUpper Tolerable Daily Limit YearResearch
Australian Complementary Medicines Evaluation Committee100mg2022Peripheral neuropathy with supplementary vitamin B6 (pyridoxine)
European Food Safety Authority (EFSA)25mg2018Summary of Tolerable Upper Intake Levels – version 4 (September 2018)
European Food Safety Authority (EFSA)Proposed 12mg Jan.
2023
Draft scientific opinion on the Tolerable Upper Intake Level
2 for vitamin B6
France2mgEU’s Proposed Safe Limit For Vitamin B6 In Supplements 8 Times Lower Than US Cap
Germany Proposed 3.5mgProposed levels for the addition of vitamin B6 to foods including food supplements
Ireland25mg2020The Safety of Vitamins and Minerals in Food Supplements – Establishing Tolerable Upper Intake Levels and a Risk Assessment Approach for Products Marketed in Ireland (Revision 2)
Italy9.5mg2013Italy ups maximum levels for vitamin D, B6 and iron in food supplements
Netherlands21mg2018Maximum daily dose of vitamin B6 in dietary supplements has now been legally established in the Netherlands
New Zealand National Health and Medical Research Council50mg2006Nutrient Reference Values for Australia and New Zealand
Norwegian Scientific Committee for Food Safety (VKM)25mg2017Assessment of vitamin B6 intake in relation to tolerable upper intake levels
Japanese Ministry of Health, Labour and Welfare60mg2015Dietary Reference Intakes for Japanese (2015) Ministry of Health, Labour and Welfare
Poland19mgEU’s Proposed Safe Limit For Vitamin B6 In Supplements 8 Times Lower Than US Cap
UK- The Expert Group on Vitamins and Minerals (EVM) 10mg2003Safe Upper Levels for Vitamins and Minerals
United States Food and Nutrition Board of the Institute of Medicine100mg1998Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline.
World Health Organization (WHO) & Food and Agriculture Organization
of the United Nations (FAO)		100mg2004

Government Agency Actions Taken

CountryAuthorityAction Taken
AustraliaTGAWarning label required for any product containing 10mg or more of B6.
Next: Member Participation in Research

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