As per the Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of Vitamin B6 (Nov, 2000), “Coleman et al. (1985) treated 400 patients with Down’s syndrome with vitamin B5 as pharmacological doses (35 mg/kg/day). Reported side effects included skin blisters that were related to sun exposure, vomiting and peripheral neuropathy; all patients who developed blisters did so after a minimum of four years of treatment. Two patients developed motor and sensory polyneuropathy after nine years administration of doses up to 50 mg/kg and their condition improved once vitamin B6 administration had stopped.”
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