The research shows that B6 deficiency symptoms are not the same of B6 toxicity symptoms. The idea that deficiency causes neuropathy got into the literature based on a handful of isolated case studies that were not likely related to B6 deficiency. Read below for more information on this.
“There are a few isolated case reports, but these were likely related to other underlying health conditions. Previously, it was suggested that demyelinating peripheral neuropathy in elderly patients on chronic peritoneal dialysis may have been caused by a vitamin B-6 deficiency. However, peripheral neuropathy in patients on dialysis has also been attributed to uremic intoxication, hormonal imbalances, disruptions in ion concentration gradients, and/or other vitamin deficiencies. In rhesus monkeys, the animal model most relevant to humans, a vitamin B-6 deficiency did not induce neuropathy. Most of the evidence in favor of an association between vitamin B-6 deficiency and neuropathy in humans is related to pharmaceutical interventions.”
“Literature on neuropathy attributed to primary pyridoxine deficiency is scant. Although pyridoxine deficiency anemia was well known by the 1950s, the only patient with pyridoxine-responsive anemia and neuropathy was reported in 1963. This single reported patient had a significant preceding weight loss and was from a low-income social background. She may have had other coexisting nutritional deficiencies, which were not investigated. There are no other case reports attributing neuropathy primarily to pyridoxine deficiency. Other reported patients with pyridoxine deficiency neuropathy had either coexisting nutritional deficiencies and medical conditions predisposing to neuropathy or were taking medications interfering with pyridoxine.”