Animal Studies

As per the Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of Vitamin B6 (Nov 2000), “Krinkle and Fitzgerald (1988) have shown that the type of neurotoxicity produced by pyridoxine in the rat is a function of the dose and duration of administration. Rats administered single high doses (1200 mg/kg) of pyridoxine were observed to have neuronopathy (damage to the cell body), those administered lower chronic doses (200 mg/kg for 12 weeks) were observed to have axonopathy to the distal portion of sensory nerves. These workers also reported that animals administered pyridoxine for five days a week had considerably less damage than those dosed every day”.

Articles on B6 and animal studies:

Dietary Excess of Vitamin B-6 Affects the Concentrations of Amino Acids in the Caudate Nucleus and Serum and the Binding Properties of Serotonin Receptors in the Brain Cortex of Rats 

Effects of Vitamin B-6 Deficiency and 4′- Deoxypyridoxine on Pyridoxal Phosphate Concentrations, Pyridoxine Kinase and other Aspects of Metabolism in the Rat

Ultrastructural Lesions of Pyridoxine Toxicity in Beagle Dogs Beagles-Damage-to-Cells (PDF)

The Behavior of Muscle Phosphorylase as a Reservoir for Vitamin B6 in the Rat

Effects of Excess Vitamin B6 Intake on Cerebral Cortex Neurons in Rat: An Ultrastructural Study

Thyroid Function in Pyridoxine-Deficient Young Rats

Hypothyroidism of Hypothalamic Origin in Pyridoxine-Deficient Rats

An Investigation of Selected Toxic Effects of Pyridoxal and Pyridoxine in the Sprague-Dawley Rat

Pyridoxine (Vitamin B6) Neurotoxicity: Enhancement by Protein-Deficient Diet

Pathologic Processes of Lumbar Primary Sensory Neurons Produced by High Doses of Pyridoxine in Rats

Pyridoxine Induced Neuropathy by Subcutaneous Administration in Dogs

High-Dosage Pyridoxine-Induced Auditory Neuropathy and Protection with Coffee in Mice

Pyridoxine-Induced Neuropathy in Rats: A Sensory Neuropathy that Responds to 4-Methylcatechol

Pyridoxine-Induced Toxicity in Rats: A Stereological Quantification of the Sensory Neuropathy

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