“Tissue injury results in the release of numerous proinflammatory mediators from the injured cells, mast cells, leukocytes, and the nerve terminals. These substances include the tachykinins, bradykinin, prostaglandins, serotonin, histamine, as well as the release of CGRP and substance P from the nerve endings”.
Read more in The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine.